| 英文名 |
[butirosin acyl-carrier protein]-L-glutamate ligase |
| Example Structure |
![Example Structure of [butirosin acyl-carrier protein]-L-glutamate ligase EC#: 6.2.1.39](/wp-content/uploads/enzyme-structure/6.2.1.39.jpg) |
| 别名 |
BtrJ, [BtrI acyl-carrier protein]L-glutamate ligase |
| EC Number |
6.2.1.39 |
| CAS编号 |
|
| Comments |
Catalyses two steps in the biosynthesis of the side chain of the aminoglycoside antibiotics of the butirosin family. The enzyme adds one molecule of?L-glutamate to a dedicated acyl-carrier protein, and following decarboxylation of the product by EC?4.1.1.95,?L-glutamyl-[BtrI acyl-carrier protein] decarboxylase, adds a second?L-glutamate molecule. Requires Mg2+?or Mn2+, and activity is enhanced in the presence of Mn2+. |
| Cofactor |
Mn2+?or?Mg2+ |
| History |
|
| Reactions |
(1) Atp + L-glutamate + [BtrI acyl-carrier protein] = adp + phosphate + L-glutamyl-[BtrI acyl-carrier protein]. (2) Atp + L-glutamate + 4-amino butanoyl-[BtrI acyl-carrier protein] = Adp + phosphate + 4-(L-gamma-glutamylamino)butanoyl-[BtrI acyl-carrier protein]. |
