| 英文名 |
carboxynorspermidine synthase |
| Example Structure |
 |
| 别名 |
ASA-DAP Schiff base reductase, Atu4170, C-NSPD synthase, CANSDH, carboxy(nor)spermidine dehydrogenase, carboxynorspermidine dehydrogenase, carboxynorspermidine synthase, carboxyspermidine dehydrogenase, CASDH, VC1624 |
| EC Number |
1.5.1.43 |
| CAS编号 |
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| Comments |
The reaction takes place in the opposite direction. Part of a bacterial polyamine biosynthesis pathway. L-aspartate 4-semialdehyde and propane-1,3-diamine/putrescine form a Schiff base that is reduced to form carboxynorspermidine/carboxyspermidine, respectively [1]. The enzyme from the bacterium Vibrio cholerae is essential for biofilm formation [2]. The enzyme from Campylobacter jejuni only produces carboxyspermidine in vivo even though it also can produce carboxynorspermidine in vitro [3]. |
| Cofactor |
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| History |
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| Reactions |
(1) Carboxynorspermidine + H(2)O + NADP(+) = L-aspartate 4-semialdehyde + propane-1,3-diamine + Nadph. (2) Carboxyspermidine + H(2)O + NADP(+) = L-aspartate 4-semialdehyde + putrescine + Nadph. |
