| 英文名 |
caspase-6 |
| Example Structure |
 |
| 别名 |
apoptotic protease Mch-2, C14.005, Cas6, Casp-6, Casp.6, Casp6, caspase 6, caspase-6, caspase-6A, caspase-6B, Csp-6, Csp6, MCH2, VEIDase |
| EC Number |
3.4.22.59 |
| CAS编号 |
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| Comments |
Caspase-6 is an effector/executioner caspase, as are caspase-3 (EC?3.4.22.56) and caspase-7 (EC?3.4.22.60) [2]. These caspases are responsible for the proteolysis of the majority of cellular polypeptides, [e.g. poly(ADP-ribose) polymerase (PARP)], which lead to the apoptotic phenotype [2]. Caspase-6 can cleave its prodomain to produce mature caspase-6, which directly activates caspase-8 (EC?3.4.22.61) and leads to cytochrome?c?release from the mitochondria. The release of cytochrome?c?is an essential component of the intrinsic apoptosis pathway [1]. The enzyme can also cleave and inactivate lamins, the intermediate filament scaffold proteins of the nuclear envelope, leading to nuclear fragementation in the final phases of apoptosis [2,4,5,6]. Belongs in peptidase family?C14. |
| Cofactor |
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| History |
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| Reactions |
Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp-|-. |
