| 英文名 |
cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming] |
| Example Structure |
![Example Structure of cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming] EC#: 1.14.15.29](/wp-content/uploads/enzyme-structure/1.14.15.29.jpg) |
| 别名 |
cholest-4-en-3-one 26-monooxygenase, CYP125, CYP125A1, CYP125A3, CYP125A4, cytochrome P450 125, Rv3545c, steroid C26-monooxygenase |
| EC Number |
1.14.15.29 |
| CAS编号 |
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| Comments |
A cytochrome P450 (heme-thiolate) protein found in several bacterial pathogens. The enzyme is involved in degradation of the host’s cholesterol. It catalyses the hydroxylation of the C-26 carbon, followed by oxidation of the alcohol to the carboxylic acid via the aldehyde intermediate, initiating the degradation of the alkyl side-chain of cholesterol [4]. The products are exclusively in the (25S) conformation. The enzyme is part of a two-component system that also includes a ferredoxin reductase (most likely KshB, which also interacts with EC 1.14.15.30, 3-ketosteroid 9¦Á-monooxygenase). The enzyme also accepts cholesterol as a substrate. cf. EC 1.14.15.28, cholest-4-en-3-one 27-monooxygenase. |
| Cofactor |
heme-thiolate |
| History |
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| Reactions |
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