| 英文名 |
cholesterol-5,6-oxide hydrolase |
| Example Structure |
 |
| 别名 |
anti-estrogen binding site, CEHase, ChEH, cholEH, cholesterol 5alpha,6alpha-oxide hydrolase, cholesterol epoxide hydrolase, cholesterol oxide hydrolase, cholesterol-5,6-epoxide hydrolase, cholesterol-epoxide hydrolase, EH_CH |
| EC Number |
3.3.2.11 |
| CAS编号 |
|
| Comments |
The enzyme appears to work equally well with both diastereoisomers of cholesterol 5,6-epoxide [3]. The product is a competitive inhibitor of the reaction. In vertebrates, five epoxide-hydrolase enzymes have been identified to date: EC?3.3.2.6?(leukotriene-A4?hydrolase), EC?3.3.2.7?(hepoxilin-epoxide hydrolase), EC?3.3.2.9?(microsomal epoxide hydrolase), EC?3.3.2.10?(soluble epoxide hydrolase) and EC?3.3.2.11?(cholesterol 5,6-oxide hydrolase) [3]. |
| Cofactor |
|
| History |
|
| Reactions |
(1) 5,6-alpha-epoxy-5-alpha-cholestan-3-beta-ol + H(2)O = cholestane-3- beta,5-alpha,6-beta-triol. (2) 5,6-beta-epoxy-5-beta-cholestan-3-beta-ol + H(2)O = cholestane-3- beta,5-alpha,6-beta-triol. |
