cullin-RING-type E3 NEDD8 transferase EC#: 2.3.2.32; 凯望编码 (ChemWhat Code): 1377194

英文名 cullin-RING-type E3 NEDD8 transferase
Example Structure Example Structure of cullin-RING-type E3 NEDD8 transferase EC#: 2.3.2.32
别名 cullin 2-RBX1 E3 ligase, DCN-1, Dcn1, Dcn1p, DCUN1D1, HRT1, Nedd8 E3 ligase, RBX-1, RBX1, ROC1, SCCRO
EC Number 2.3.2.32
CAS编号
Comments Some RING-type E3 ubiquitin transferase (EC 2.3.2.27) are not able to bind a substrate protein directly. Instead, they form a complex with a cullin scaffold protein and a substrate recognition module, which is named CRL for Cullin-RING-Ligase. The cullin protein needs to be activated by the ubiquitin-like protein NEDD8 in a process known as neddylation. The transfer of NEDD8 from a NEDD8-specific E2 enzyme onto the cullin protein is a secondary function of the RING-type E3 ubiquitin transferase in the CRL complex. The process requires auxiliary factors that belong to the DCN1 (defective in cullin neddylation 1) family.
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