D-2-hydroxyacid dehydrogenase (NAD+) EC#: 1.1.1.345; 凯望编码 (ChemWhat Code): 1373462

英文名 D-2-hydroxyacid dehydrogenase (NAD+)
Example Structure Example Structure of D-2-hydroxyacid dehydrogenase (NAD+) EC#: 1.1.1.345
别名
EC Number 1.1.1.345
CAS编号
Comments The enzymes, characterized from bacteria (Peptoclostridium difficile, Enterococcus faecalis and from lactic acid bacteria) prefer substrates with a main chain of 5 carbons (such as 4-methyl-2-oxopentanoate) to those with a shorter chain. It also utilizes phenylpyruvate. The enzyme from the halophilic archaeon Haloferax mediterranei prefers substrates with a main chain of 3-4 carbons (pyruvate and 2-oxobutanoate). cf. EC 1.1.1.272, D-2-hydroxyacid dehydrogenase (NADP+).
Cofactor
History
Reactions An (R)-2-hydroxcarboxylate + NAD(+) = a 2-oxocarboxylate + Nadh.

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