| 英文名 |
D-alanine-D-serine ligase |
| Example Structure |
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| 别名 |
D-alanine:D-serine ligase, VanC2, vanC2/3, VanE, VanG, vanGCar, VanL |
| EC Number |
6.3.2.35 |
| CAS编号 |
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| Comments |
The product of this enzyme,?D-alanyl-D-serine, can be incorporated into the peptidoglycan pentapeptide instead of the usual?D-alanyl-D-alanine dipeptide, which is formed by EC?6.3.2.4,?D-alanine¡ªD-alanine ligase. The resulting peptidoglycan does not bind the glycopeptide antibiotics vancomycin and teicoplanin, conferring resistance on the bacteria. |
| Cofactor |
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| History |
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| Reactions |
D-alanine + D-serine + Atp = D-alanyl-D-serine + adp + phosphate. |
