| 别名 |
D-Ala-D-Lac ligase, D-Ala:D-Lac ligase, D-alanine-D-lactate ligase, D-alanine:D-alanine (D-lactate) ligase (ADP), D-alanine:D-lactate ligase, D-alanyl-D-lactate ligase, depsipeptide ligase, VanA, VanB, VanD, VanD4, VanI, VRSA-9 Ddl |
| Comments |
The product of this enzyme, the depsipeptide?D-alanyl-(R)-lactate, can be incorporated into the peptidoglycan pentapeptide instead of the usual?D-alanyl-D-alanine dipeptide, which is formed by EC?6.3.2.4,?D-alanine¡ªD-alanine ligase. The resulting peptidoglycan does not bind the glycopeptide antibiotics vancomycin and teicoplanin, conferring resistance on the bacteria. |
