| 英文名 |
dapdiamide synthase |
| Example Structure |
 |
| 别名 |
DdaF, {[(2E)-4-amino-4-oxobut-2-enoyl]amino}-L-alanine:L-valine ligase (ADP-forming) |
| EC Number |
6.3.2.47 |
| CAS编号 |
|
| Comments |
The enzyme, characterized from the bacterium?Pantoea agglomerans, is involved in biosynthesis of dapdiamide tripeptide antibiotics, a family of fumaramoyl- and epoxysuccinamoyl-peptides named for the presence of an (S)-2,3-diaminopropanoate (DAP) moiety and two amide linkages in their scaffold. |
| Cofactor |
|
| History |
|
| Reactions |
(1) Atp + 3-((((2R,3R)-3-carboxyoxiran-2-yl)carbonyl)amino)-L-alanine + L-valine = Adp + phosphate + 3-((((2R,3R)-3-carboxyoxiran-2- yl)carbonyl)amino)-L-alanyl-L-valine. (2) Atp + 3-(((2E)-4-amino-4-oxobut-2-enoyl)amino)-L-alanine + L-valine = Adp + phosphate + 3-(((2E)-4-amino-4-oxobut-2-enoyl)amino)-L-alanyl-L- valine. (3) Atp + 3-(((2E)-4-amino-4-oxobut-2-enoyl)amino)-L-alanine + L-isoleucine = Adp + phosphate + 3-(((2E)-4-amino-4-oxobut-2- enoyl)amino)-L-alanyl-L-isoleucine. (4) Atp + 3-(((2E)-4-amino-4-oxobut-2-enoyl)amino)-L-alanine + L-leucine |
