| 英文名 |
dichloroarcyriaflavin A synthase |
| Example Structure |
 |
| 别名 |
CYP245A1, cytochrome P450 StaP, P450 StaP, StaP |
| EC Number |
1.13.12.17 |
| CAS编号 |
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| Comments |
The conversion of dichlorochromopyrrolate to dichloroarcyriaflavin A is a complex process that involves two enzyme components. RebP is an NAD-dependent cytochrome P450 oxygenase that performs an aryl-aryl bond formation yielding the six-ring indolocarbazole scaffold [1]. Along with RebC, a flavin-dependent hydroxylase, it also catalyses the oxidative decarboxylation of both carboxyl groups. The presence of RebC ensures that the only product is the rebeccamycin aglycone dichloroarcyriaflavin A [2]. The enzymes are similar, but not identical, to StaP and StaC, which are involved in the synthesis of staurosporine [3]. |
| Cofactor |
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| History |
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| Reactions |
Dichlorochromopyrrolate + 4 O(2) + 4 Nadh = dichloroarcyriaflavin a + 2 CO(2) + 6 H(2)O + 4 NAD(+). |
