| 英文名 |
dihydroceramide fatty acyl 2-hydroxylase |
| Example Structure |
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| 别名 |
AtFAH1, FAH1, FAH2, fatty acid 2-hydroxylase 1, plant sphingolipid fatty acid 2-hydroxylase |
| EC Number |
1.14.18.7 |
| CAS编号 |
|
| Comments |
The enzyme, characterized from plants, catalyses the hydroxylation of carbon 2 of long- or very-long-chain fatty acids attached to sphinganine during de novo ceramide synthesis. The enzyme requires an external cytochrome b5 as the electron donor. The newly introduced 2-hydroxyl group has R-configuration. cf. EC 1.14.18.6, 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase. |
| Cofactor |
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| History |
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| Reactions |
A dihydroceramide + 2 ferrocytochrome b5 + O(2) + 2 H(+) = a (2’R)- 2′-hydroxydihydroceramide + 2 ferricytochrome b5 + H(2)O. |
