| 英文名 |
dihydropyrimidine dehydrogenase (NAD+) |
| Example Structure |
 |
| 别名 |
dehydrogenase, dihydrouracil, dihydropyrimidine dehydrogenase, dihydrothymine dehydrogenase, dihydrouracil dehydrogenase (NAD+), DPD, pyrimidine deaminase/reductase, pyrimidine reductase, RibD, thymine reductase, uracil reductase |
| EC Number |
1.3.1.1 |
| CAS编号 |
9026-89-5 |
| Comments |
An iron-sulfur flavoenzyme. The enzyme was originally discovered in the uracil-fermenting bacterium, Clostridium uracilicum, which utilizes uracil and thymine as nitrogen and carbon sources for growth [1]. Since then the enzyme was found in additional organisms including Alcaligenes eutrophus [2], Pseudomonas strains [3,4] and Escherichia coli [5,6]. |
| Cofactor |
flavoprotein;iron-sulfur |
| History |
|
| Reactions |
(1) 5,6-dihydrouracil + NAD(+) = uracil + Nadh. (2) 5,6-dihydrothymine + NAD(+) = thymine + Nadh. |
