| 英文名 |
dimethylglycine dehydrogenase |
| Example Structure |
 |
| 别名 |
DMGDH, Me2GlyDH, mMe2GlyDH, N,N-dimethylglycine oxidase, pMe2GlyDH |
| EC Number |
1.5.8.4 |
| CAS编号 |
37256-30-7 |
| Comments |
A flavoprotein, containing a histidyl(N¦Ð)-(8¦Á)FAD linkage at position 91 in the human protein. An imine intermediate is channeled from the FAD binding site to the 5,6,7,8-tetrahydrofolate binding site through a 40 ? tunnel [7,8,9]. In the absence of 5,6,7,8-tetrahydrofolate the enzyme forms formaldehyde [7,9]. |
| Cofactor |
FAD |
| History |
|
| Reactions |
N,N-dimethylglycine + 5,6,7,8-tetrahydrofolate + electron-transfer flavoprotein = sarcosine + 5,10-methylenetetrahydrofolate + reduced electron-transfer flavoprotein. |
