| 英文名 |
diphthine methyl ester synthase |
| Example Structure |
 |
| 别名 |
diphthine methyltransferase, Dph5, S-adenosyl-L-methionine:elongation factor 2 methyltransferase |
| EC Number |
2.1.1.314 |
| CAS编号 |
|
| Comments |
This eukaryotic enzyme is part of the biosynthetic pathway of diphthamide. Different from the archaeal enzyme, which performs only 3 methylations, producing diphthine (cf. EC 2.1.1.98). The relevant histidine of elongation factor 2 is His715 in mammals and His699 in yeast. |
| Cofactor |
|
| History |
|
| Reactions |
4 S-adenosyl-L-methionine + 2-((3S)-3-carboxy-3-aminopropyl)-L-histidine- [translation elongation factor 2] = 4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2]. |
