| 英文名 |
dolichyl-P-Man:Man5GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase |
| Example Structure |
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| 别名 |
Alg3, Alg3p, AtALG3, Dol-P-Man:Man5GlcNAc2-PP-Dol alpha1,3-mannosyl transferase, Dol-P-Man:Man5GlcNAc2-PP-Dol mannosyltransferase, dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase, Not56-like protein, PpAlg3 alpha-1,3-mannosyl transferase, TbALG3 |
| EC Number |
2.4.1.258 |
| CAS编号 |
77967-76-1 |
| Comments |
The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide on the lipid carrier dolichyl diphosphate. Early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man5GlcNAc2-PP-dolichyl to Man9Glc-NAc2-PP-dolichyl on the lumenal side use dolichyl ¦Â-D-mannosyl phosphate. The first step of this assembly pathway on the luminal side of the endoplasmic reticulum is catalysed by ALG3. |
| Cofactor |
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| History |
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| Reactions |
Dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha- (1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D- GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Man-alpha-(1->2)-D-Man- alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->3)-D-Man-alpha-(1->6))- D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. |
