| 英文名 |
dolichyl-P-Man:Man6GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase |
| Example Structure |
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| 别名 |
ALG9, ALG9 alpha1,2 mannosyltransferase, ALG9 mannosyltransferase, dolichylphosphomannose-dependent ALG9 mannosyltransferase, EBS3 |
| EC Number |
2.4.1.259 |
| CAS编号 |
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| Comments |
The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide on the lipid carrier dolichyl diphosphate. Early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man5GlcNAc2-PP-dolichol to Man9Glc-NAc2-PP-dolichol on the lumenal side use dolichyl ¦Â-D-mannosyl phosphate. ALG9 mannosyltransferase catalyses the addition of two different ¦Á-1,2-mannose residues – the addition of ¦Á-1,2-mannose to Man6GlcNAc2-PP-dolichol (EC 2.4.1.259) and the addition of ¦Á-1,2-mannose to Man8GlcNAc2-PP-dolichol (EC 2.4.1.261). |
| Cofactor |
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| History |
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| Reactions |
Dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha- (1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->3)-D-Man-alpha-(1->6))-D-Man- beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Man- alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D- Man-alpha-(1->3)-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta- (1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. |
