| 英文名 |
dolichyl-phosphooligosaccharide-protein glycotransferase |
| Example Structure |
 |
| 别名 |
AF_0380, AglB, AglB-L, AlgB, archaeal oligosaccharyl transferase, dolichyl-monophosphooligosaccharide-protein glycotransferase, Mv1749, MVO1749 |
| EC Number |
2.4.99.21 |
| CAS编号 |
|
| Comments |
The enzyme, characterized from the archaea Methanococcus voltae and Haloferax volcanii, transfers a glycan component from dolichyl phosphooligosaccharide to external proteins. It is different from EC 2.4.99.18, dolichyl-diphosphooligosaccharide-protein glycotransferase, which uses dolichyl diphosphate as carrier compound in bacteria and eukaryotes. The enzyme participates in the N-glycosylation of proteins in some archaea. It requires Mn2+. Dolichol used by archaea is different from that used by eukaryotes. It is much shorter (C55-C60), it is ¦Á,¦Ø-saturated and it may have additional unsaturated positions in the chain. |
| Cofactor |
Mn2+ |
| History |
|
| Reactions |
An archaeal dolichyl phosphooligosaccharide + [protein]-L-asparagine = an archaeal dolichyl phosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine. |
