| 英文名 |
F-actin monooxygenase |
| Example Structure |
 |
| 别名 |
MICAL, MICAL-1, MICAL-2, MICAL1, Mical2 |
| EC Number |
1.14.13.225 |
| CAS编号 |
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| Comments |
The enzyme, characterized from the fruit fly Drosophila melanogaster, is a multi-domain oxidoreductase that acts as an F-actin disassembly factor. The enzyme selectively reduces two L-Met residues of F-actin, causing fragmentation of the filaments and preventing repolymerization [1]. Free methionine is not a substrate [2]. The reaction is stereospecific and generates the (R)-sulfoxide [3]. |
| Cofactor |
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| History |
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| Reactions |
[F-actin]-L-methionine + Nadph + O(2) + H(+) = [F-actin]-L-methionine- (R)-S-oxide + NADP(+) + H(2)O. |
