fatty-acyl-CoA synthase system EC#: 2.3.1.86 • ChemWhat

fatty-acyl-CoA synthase system EC#: 2.3.1.86; 凯望编码 (ChemWhat Code): 1376858


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英文名	fatty-acyl-CoA synthase system
Example Structure
别名	CpFas2, FAS, FAS1, fas2, fatty acid synthase, fatty-acyl-CoA synthase, yeast fatty acid synthase
EC Number	2.3.1.86
CAS编号	9045-77-6
Comments	The enzyme from yeasts (Ascomycota and Basidiomycota) is a multi-functional protein complex composed of two subunits. One subunit catalyses the reactions EC 1.1.1.100, 3-oxoacyl-[acyl-carrier-protein] reductase and EC 2.3.1.41, 3-oxoacyl-[acyl-carrier-protein] synthase, while the other subunit catalyses the reactions of EC 2.3.1.38, [acyl-carrier-protein] S-acetyltransferase, EC 2.3.1.39, [acyl-carrier-protein] S-malonyltransferase, EC 4.2.1.59, 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase, EC 1.3.1.10, enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) and EC 1.1.1.279, (R)-3-hydroxyacid ester dehydrogenase.The enzyme differs from the animal enzyme (EC 2.3.1.85) in that the enoyl reductase domain requires FMN as a cofactor, and the ultimate product is an acyl-CoA (usually palmitoyl-CoA) instead of a free fatty acid.
Cofactor
History
Reactions	Acetyl-CoA + n malonyl-CoA + 2n Nadph = long-chain-acyl-CoA + n CoA + n CO(2) + 2n NADP(+).