Furin EC#: 3.4.21.75 • ChemWhat中文网 | 凯望化学与生物数据库

Furin EC#: 3.4.21.75; 凯望编码 (ChemWhat Code): 1380593


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英文名	Furin
Example Structure
别名	Bfurin, Dfurin1, Dibasic processing enzyme, FUR, furin, furin A, furin B, furin convertase, furin protease, furin-like prohormone convertase, furin-like proprotein convertase, furin-like protease, FurinA, furinase, hfurin, KPC-1, More, PACE, Paired basic amino acid cleaving enzyme, Paired basic amino acid converting enzyme, Paired basic amino acid residue cleaving enzyme, PC1, PC1/3, PC2, PCSK3, proconvertase, prohormone convertase, prohormone convertase 1, prohormone convertase 2, Proprotein convertase, proprotein convertase subtilisin/kexin type 3, proprotein convertase subtilisin/kexin type3, Serine proteinase PACE, Sfurin, sheddase, SPC3, subtilisin-like proprotein convertase, subtilisin-like protein convertase, Trans golgi network protease furin
EC Number	3.4.21.75
CAS编号	141760-45-4
Comments	One of a group of peptidases in peptidase family?S8?(subtilisin family) that is structurally and functionally similar to kexin. All are activated by Ca2+, contain Cys near the active site His, and are inhibited by?p-mercuribenzoate. At least three related enzymes are recognized in mammals: PC2, PC3 and PC4, which have somewhat different specificities.
Cofactor
History
Reactions	Release of mature proteins from their proproteins by cleavage of -Arg- Xaa-Yaa-Arg-\|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.