gamma-glutamyltransferase EC#: 2.3.2.2; 凯望编码 (ChemWhat Code): 1377140
| 英文名 | gamma-glutamyltransferase |
| Example Structure | ![]() |
| 别名 | (5-L-glutamyl) peptide: amino-acid 5-glutamyl transferase, alpha-glutamyl transpeptidase, At1g69820, At4g29210, At4g39640, At4g39650, gamma glutamyl transferase, gamma-glutamyl peptidyltransferase, gamma-glutamyl transferase, gamma-glutamyl transferase 5, gamma-glutamyl transferases, gamma-glutamyl transpeptidase, gamma-glutamyl transpeptidase 4, gamma-glutamyl transpeptidase-1, gamma-glutamyltranspeptidase, gamma-GPT, gamma-GT, gamma-GTase, gamma-GTP, gammaGT, GGT, GGT A, GGT I, GGT-1, GGT1, GGT2, GGT3, GGT4, GGT5, GGTII protein, GGTLA1, glutamyl transpeptidase, glutamyltransferase, gamma-, L-gamma-glutamyl transpeptidase, L-gamma-glutamyltransferase, L-glutamyltransferase |
| EC Number | 2.3.2.2 |
| CAS编号 | 9046-27-9 |
| Comments | The mammlian enzyme is part of the cell antioxidant defense mechanism. It initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracelular GSH levels. The protein also has EC 3.4.19.13 (glutathione hydrolase) activity [3-4]. The enzyme consists of two chains that are created by the proteolytic cleavage of a single precursor polypeptide. The N-terminal L-threonine of the C-terminal subunit functions as the active site for both the cleavage and the hydrolysis reactions [3-4]. |
| Cofactor | |
| History | |
| Reactions | A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid. |
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