Geneticin CAS#: 108321-42-2; 凯望编码 (ChemWhat Code): 18950

IdentificationPhysical DataSpectra
Route of Synthesis (ROS)Safety and HazardsOther Data

Identification

英文名Geneticin
IUPAC Name(2S,3S,4S,5S)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(1-hydroxyethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid
分子结构
CAS编号 108321-42-2
EINECS NumberNo data available
MDL NumberMFCD28168024
Beilstein Registry NumberNo data available
别名(2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-[(1R)-1-hydroxyethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid
G-418 sulfate; G-418 (disulfate); G-418 disulfate; G418 Disulfate; G 418 disulfate salt; MFCD05664725; (2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-[(1R)-1-hydroxyethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid; Antibiotic G-418, sulfate (salt); G-418 disulfate?; ANTIBIOTIC G-418 SULFATE; AKOS024457991; G418 disulfate, Cell Culture Reagent; HY-17561; (2R,3S,4R,5R,6S)-5-Amino-6-(((1R,2S,3S,4R,6S)-4,6-diamino-3-(((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydro-2H-pyran-2-yl)oxy)-2-hydroxycyclohexyl)oxy)-2-((R)-1-hydroxyethyl)tetrahydro-2H-pyran-3,4-diol bis(sulfate); (2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-[(1R)-1-hydroxyethyl]tetrahydropyran-2-yl]oxy-2-hydroxy-cyclohexoxy]-5-methyl-4-(methylamino)tetrahydropyran-3,5-diol;sulfuric acid; (2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-[(1R)-1-hydroxyethyl]-2-oxanyl]oxy]-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid; (2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4,6-bis(azanyl)-3-[(2S,3R,4R,5S,6R)-3-azanyl-4,5-bis(oxidanyl)-6-[(1R)-1-oxidanylethyl]oxan-2-yl]oxy-2-oxidanyl-cyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid
分子式C20H44N4O18S2
分子量692.702
InChIInChI=1S/C20H40N4O10.2H2O4S/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19;21-5(2,3)4/h6-19,24-30H,4-5,21-23H2,1-3H3;2(H2,1,2,3,4)/t6-,7+,8-,9-,10-,11+,12+,13-,14-,15-,16+,17-,18-,19-,20+;;/m1../s1
InChI KeyUHEPSJJJMTWUCP-DHDYTCSHSA-N
Canonical SMILESCN[C@@H]1C@@HC@@HO)C@@HC@H[C@H]3N)C@@HC[C@H]2N)OC[C@]1(C)O.O=S(=O)(O)O.O=S(=O)(O)O
Patent Information
No data available

Physical Data

AppearanceWhite powder
SolubilityH2O:50 mg/mL
Flash PointNo data available
Refractive indexNo data available
SensitivityNo data available

Spectra

No data available

Route of Synthesis (ROS)

No data available

Safety and Hazards

Pictogram(s)exclamation-markhealth-hazard
SignalDanger
GHS Hazard StatementsH315 (25%): Causes skin irritation [Warning Skin corrosion/irritation]
H317 (93.1%): May cause an allergic skin reaction [Warning Sensitization, Skin]
H319 (25%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H334 (81.9%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]
H360 (13.9%): May damage fertility or the unborn child [Danger Reproductive toxicity]
Information may vary between notifications depending on impurities, additives, and other factors.
Precautionary Statement CodesP203, P233, P260, P261, P264, P264+P265, P271, P272, P280, P284, P302+P352, P304+P340, P305+P351+P338, P318, P321, P332+P317, P333+P317, P337+P317, P342+P316, P362+P364, P403, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
SDS DownloadEnglish Version

Other Data

TransportationNONH for all modes of transport
Under the room temperature and away from light
HS CodeNo data available
StorageUnder the room temperature and away from light
Shelf Life2 years
Market PriceUSD
Use Pattern
Geneticin CAS#: 108321-42-2, an aminoglycoside antibiotic, is an inhibitor of 80 S ribosomes extension. It can block polypeptide synthesis by inhibiting the extension step in both prokaryotic and eukaryotic cells. It blocks polypeptide synthesis by interfering with ribosome function. It is not a commonly used standard antibiotic, but is often used to select prokaryotic and eukaryotic cells transfected with neomycin resistance genes. It is widely used in gene transfer, gene knockout, resistance screening, and transgenic animals.

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