globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase EC#: 2.4.1.79; 凯望编码 (ChemWhat Code): 1377358
| 英文名 | globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase |
| Example Structure |  |
| 别名 | acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide, acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-glycosphingolipid, beta(1->3) N-acetylgalactosaminyltransferase, beta1,3GalNAc-T, galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase, GalNAc transferase, globoside N-acetylgalactosaminyltransferase, globoside synthetase, glycosphingolipid beta-N-acetylgalactosaminyltransferase, UDP-N-acetylgalactosamine:globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase, UDP-N-acetylgalactosamine:globotriaosylceramide beta-3-N-acetylgalactosaminyltransferase |
| EC Number | 2.4.1.79 |
| CAS编号 | 62213-46-1 |
| Comments | Globoside is a neutral glycosphingolipid in human erythrocytes and has blood-group-P-antigen activity [4]. The enzyme requires a divalent cation for activity, with Mn2+ required for maximal activity [3]. UDP-GalNAc is the only sugar donor that is used efficiently by the enzyme: UDP-Gal and UDP-GlcNAc result in very low enzyme activity [3]. Lactosylceramide, globoside and gangliosides GM3 and GD3 are not substrates [4]. For explanation of the superscripted ‘3’ in the systematic name, see GL-5.3.4. |
| Cofactor | Mn2+ |
| History | |
| Reactions | UDP-N-acetyl-alpha-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D- galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = Udp + N-acetyl-beta- D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl- (1->4)-beta-D-glucosyl-(1<->1)-ceramide. |
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