| 英文名 |
glucuronosyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase |
| Example Structure |
 |
| 别名 |
alpha-N-acetylglucosaminyltransferase I, alpha1,4-N-acetylglucosaminyltransferase, botv, brother of tout-velu, Galntl-1, glucuronosylgalactosylproteoglycan 4-alpha-N-acetylglucosaminyltransferase, N-acetylgalactosaminyltransferase-like 1 |
| EC Number |
2.4.1.223 |
| CAS编号 |
179241-74-8 |
| Comments |
Enzyme involved in the initiation of heparin and heparan sulfate synthesis, transferring GlcNAc to the (GlcA-Gal-Gal-Xyl-)Ser core. Apparently products of both the human EXTL2 and EXTL3 genes can catalyse this reaction. In Caenorhabditis elegans, the product of the rib-2 gene displays this activity as well as that of EC 2.4.1.224, glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-¦Á-N-acetylglucosaminyltransferase. For explanation of the use of a superscript in the systematic name, see 2-Carb-37.2. |
| Cofactor |
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| History |
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| Reactions |
UDP-N-acetyl-alpha-D-glucosamine + [protein]-3-O-(beta-D-GlcA-(1->3)- beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine = Udp + [protein]-3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal- (1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine. |
