| 英文名 |
glutamate carboxypeptidase |
| Example Structure |
 |
| 别名 |
carboxypeptidase G, carboxypeptidase G1, carboxypeptidase G2, CPDG2, CPG2, folate hydrolase G2, glucarpidase, glutamate carboxypeptidase, glutamyl carboxypeptidase, N-pteroyl-L-glutamate hydrolase, pteroylmonoglutamic acid hydrolase G2 |
| EC Number |
3.4.17.11 |
| CAS编号 |
9074-87-7 |
| Comments |
A zinc enzyme produced by pseudomonads,?Flavobacterium?sp. and?Acinetobacter?sp. Its ability to hydrolyse pteroyl-L-glutamate (folic acid) has led to its use as a folate-depleting, antitumour agent. Type example of peptidase family?M20. |
| Cofactor |
Zn2+ |
| History |
|
| Reactions |
Release of C-terminal glutamate residues from a wide range of N-acylating moieties, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl and pteroyl groups. |
