| 英文名 |
glutathione gamma-glutamate hydrolase |
| Example Structure |
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| 别名 |
At4g29210, gamma-glutamyl transpeptidase, GGT, GGT1, GGT3, GGT4, GGT5, hp1118 |
| EC Number |
3.4.19.13 |
| CAS编号 |
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| Comments |
This is a bifunctional protein that also has the activity of EC?2.3.2.2, ¦Ã-glutamyltransferase. The enzyme binds its substrate by forming an initial ¦Ã-glutamyl-enzyme intermediate, releasing the?L-cysteinylglycine part of the molecule. The enzyme then reacts with either a water molecule or a different acceptor substrate (usually an?L-amino acid or a dipeptide) to form?L-glutamate or a product containing a new ¦Ã-glutamyl isopeptide bond, respectively. The enzyme acts on glutathione, glutathione-S-conjugates, and, at a lower level, on other substrates with an N-terminal?L-¦Ã-glutamyl residue. It plays a crucial part in the glutathione-mediated xenobiotic detoxification pathway. The enzyme consists of two chains that are created by the proteolytic cleavage of a single precursor polypeptide. |
| Cofactor |
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| History |
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| Reactions |
Glutathione + H(2)O = L-cysteinylglycine + L-glutamate. |
