Glycyl-L-Histidyl-L-Lysine CAS#: 49557-75-7; 凯望编码 (ChemWhat Code): 91015
Identification
| 英文名 | Glycyl-L-Histidyl-L-Lysine |
| IUPAC Name | (2S)-6-amino-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoic acid |
| 分子结构 |  |
| CAS编号 | 49557-75-7 |
| EINECS Number | No data available |
| MDL Number | MFCD00036754 |
| Beilstein Registry Number | No data available |
| 别名 | glycyl-L-histidyl-L-lysine, glycyl-L-Histidyl-L-Lysine, Gly-L-His-L-Lys, Gly-His-Lys-OH, Gly-His-Lys, GHK, GHK-OH |
| 分子式 | C14H24N6O4 |
| 分子量 | 340.378 |
| InChI | InChI=1S/C14H24N6O4/c15-4-2-1-3-10(14(23)24)20-13(22)11(19-12(21)6-16)5-9-7-17-8-18-9/h7-8,10-11H,1-6,15-16H2,(H,17,18)(H,19,21)(H,20,22)(H,23,24)/t10-,11-/m0/s1 |
| InChI Key | MVORZMQFXBLMHM-QWRGUYRKSA-N |
| Canonical SMILES | c1c(nc[nH]1)C[C@@H](C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)CN |
| Patent Information | ||
| Patent ID | Title | Publication Date |
| US2007/4633 | Use of peptidic conjugates for preparing compositions for alopecia preventive and curative treatment | 2007 |
| US4810693 | Method for inducing biological coverings in wounds | 1989 |
Physical Data
| Appearance | White powder |
| Solubility | No data available |
| Boiling Point | 831.0±65.0 °C(Predicted) |
| Refractive index | No data available |
| Sensitivity | No data available |
| Description (Association (MCS)) | Solvent (Association (MCS)) | Temperature (Association (MCS)), °C | Partner (Association (MCS)) |
| Stability constant of the complex with … | various solvent(s) | 25 | [5,10,15,20-tetrakis(4-carboxy-3,5-bis(carboxymethoxy)phenyl)porphyrinato]zinc(II) potassium salt |
| Stability constant of the complex with … | various solvent(s) | 25 | [5,10,15,20-tetrakis(4-carboxy-3,5-bis(10-carboxydecyloxy)phenyl)porphyrinato]zinc(II) potassium salt |
| Stability constant of the complex with … | various solvent(s) | 25 | 5,10,15,20-tetrakis(4-carboxyphenyl)porphirinatozinc acetate |
| Stability constant of the complex with … | various solvent(s) | 25 | [5,10,15,20-tetrakis(4-carboxy-3,5-bis(carboxybutoxy)phenyl)porphyrinato]zinc(II) potassium salt |
Spectra
| Description (NMR Spectroscopy) | Nucleus (NMR Spectroscopy) | Solvents (NMR Spectroscopy) | Temperature (NMR Spectroscopy), °C | Frequency (NMR Spectroscopy), MHz |
| Chemical shifts, Spectrum | 13C | water-d2 | 24.84 | 125.8 |
| Chemical shifts, Spectrum | 1H | water-d2 | 24.84 | 500 |
| Chemical shifts | 1H | 300 |
| Description (Mass Spectrometry) | Comment (Mass Spectrometry) |
| MALDI (Matrix assisted laser desorption ionization), time-of-flight mass spectra (TOFMS), spectrum | |
| Molecular peak |
| Description (UV/VIS Spectroscopy) | Solvent (UV/VIS Spectroscopy) |
| Spectrum | water |
| Description (ESR Spectroscopy) | Solvents (ESR Spectroscopy) | Temperature (ESR Spectroscopy), °C |
| Spectrum | water | 25 |
Route of Synthesis (ROS)
| Conditions | Yield |
| With sodium methylate In methanol; water at 20℃; for 2h; Experimental Procedure 1 Example 1 Preparation of the peptide metalocomplex Cu-GHK 1.5 g of GHK was suspended at ambient temperature in 50 ml of 100percent methanol, while stirred continuously 0.25 g of cupric acetate (CuOAc) was added in the form of 5 ml of aqueous solution and 5 ml of MeONa (1M). The mixture was stirred at ambient temperature at the speed of 130 rpm for 120 minutes. The peptide metalocomplex was then extracted and dried. |
Safety and Hazards
| GHS Hazard Statements | Not Classified |
| Precautionary Statement Codes |
Other Data
| Transportation | Not dangerous goods |
| Under the room temperature and away from light | |
| HS Code | No data available |
| Storage | Under the room temperature and away from light |
| Shelf Life | 1 year |
| Market Price | USD |
| Druglikeness | |
| Lipinski rules component | |
| 分子量 | 340.382 |
| logP | -4.37 |
| HBA | 10 |
| HBD | 6 |
| Matching Lipinski Rules | 3 |
| Veber rules component | |
| Polar Surface Area (PSA) | 176.22 |
| Rotatable Bond (RotB) | 13 |
| Matching Veber Rules | 0 |
| Use Pattern |
| Glycyl-L-Histidyl-L-Lysine CAS#: 49557-75-7 used in cosmetics. |
| Glycyl-L-Histidyl-L-Lysine CAS#: 49557-75-7 can protect collagen from damage by activated carbon groups. |
| Glycyl-L-Histidyl-L-Lysine CAS#: 49557-75-7 can promote the growth of type III collagen. |
| Glycyl-L-Histidyl-L-Lysine CAS#: 49557-75-7 can anti-glycation |
| Glycyl-L-Histidyl-L-Lysine CAS#: 49557-75-7 is can anti-oxidation. |
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认证生产商 | |
| Apnoke Scientific Ltd | http://www.apnoke.com/ |
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