| 英文名 |
guanosine-5′-diphospho-5′-[DNA] diphosphatase |
| Example Structure |
![Example Structure of guanosine-5'-diphospho-5'-[DNA] diphosphatase EC#: 3.1.11.8](/wp-content/uploads/enzyme-structure/3.1.11.8.jpg) |
| 别名 |
aprataxin, APTX, HNT3, pp5’G5′-DNA guanylate hydrolase, pp5’G5’DNA diphosphatase |
| EC Number |
3.1.11.8 |
| CAS编号 |
|
| Comments |
Aprataxin is a DNA-binding protein that catalyses (among other activities) the 5′ decapping of Gpp-DNA (formed by homologs of RtcB3 from the bacterium?Myxococcus xanthus). The enzyme binds the guanylate group to a histidine residue at its active site, forming a covalent enzyme-nucleotide phosphate intermediate, followed by the hydrolysis of the guanylate from the nucleic acid and eventual release. The enzyme forms a 5′-phospho terminus that can be efficiently joined by “classical” ligases. The enzyme also possesses the activity of EC?3.1.11.7, DNA-(5′-diphosphoadenosine) diphosphatase and EC?3.1.12.2, DNA-3′-diphospho-5′-guanosine diphosphatase. |
| Cofactor |
|
| History |
|
| Reactions |
Guanosine-5′-diphospho-5′-(DNA) + H(2)O = phospho-5′-(DNA) + Gmp. |
