heme oxygenase (biliverdin-producing) EC#: 1.14.14.18; 凯望编码 (ChemWhat Code): 1375520
| 英文名 | heme oxygenase (biliverdin-producing) |
| Example Structure | ![]() |
| 别名 | biliverdin-producing heme oxygenase, ChuS, ChuZ, haem oxygenase, heme oxygenase, heme oxygenase 1, heme oxygenase 2, heme oxygenase-1, heme oxygenase-2, HemO, Hmox1, Hmox1a, Hmox1b, Hmox2, Hmox2a, Hmox2b, HmuO, Hmx1, HO, HO-1, HO-2, Ho1, Ho2, Ho3, HO4, HSP32, HugZ, HY1, inducible heme oxygenase-1, More, MsHO1, ORP33 proteins, oxygenase, heme (decyclizing), pbsA1, PigA, proteins, specific or class, ORP33 (oxygen-regulated protein 33,000-mol.-wt.), Syn HO-1, Syn HO-2 |
| EC Number | 1.14.14.18 |
| CAS编号 | 9059-22-7 |
| Comments | This mammalian enzyme participates in the degradation of heme. The terminal oxygen atoms that are incorporated into the carbonyl groups of pyrrole rings A and B of biliverdin are derived from two separate oxygen molecules [4]. The third oxygen molecule provides the oxygen atom that converts the ¦Á-carbon to CO. The enzyme requires NAD(P)H and EC 1.6.2.4, NADPH–hemoprotein reductase. cf. EC 1.14.15.20, heme oxygenase (biliverdin-producing, ferredoxin). |
| Cofactor | |
| History | |
| Reactions | Protoheme + 3 [reduced NADPH–hemoprotein reductase] + 3 O(2) = biliverdin + Fe(2+) + Co + 3 [oxidized NADPH–hemoprotein reductase] + 3 H(2)O. |
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