[heparan sulfate]-glucosamine 3-sulfotransferase 1 EC#: 2.8.2.23; 凯望编码 (ChemWhat Code): 1379107

英文名 [heparan sulfate]-glucosamine 3-sulfotransferase 1
Example Structure Example Structure of [heparan sulfate]-glucosamine 3-sulfotransferase 1 EC#: 2.8.2.23
别名 3′-phosphoadenylyl-sulfate:heparin-glucosamine 3-O-sulfotransferase, 3-O-sulfotransferase-1, 3-O-sulfotransferases-1, 3-OST-1, 3-OST-4, 3-OST1, 3OST1, gD-type 3-O-sulfotransferase-4, gD-type-3-OST-1, gD-type-3-OST-4, glucosaminyl 3-O-sulfotransferase, heparan sulfate 3-O-sulfotransferase, heparan sulfate 3-O-sulfotransferase 1, heparan sulfate 3-O-sulfotransferase isoform-1, heparan sulfate 3-O-sulfotransferase-1, heparan sulfate D-glucosaminyl 3-O-sulfotransferase, heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2, heparan sulfate glucosamine 3-O-sulfotransferase, heparan sulfate sulfotransferase, heparin-glucosamine 3-O-sulfotransferase, HS 3-O-sulfotransferase 1, Hs3st-1, HS3ST-2, HS3ST1, More, sulfotransferase, glucosaminyl 3-O-
EC Number 2.8.2.23
CAS编号 118113-79-4
Comments This enzyme differs from the other [heparan sulfate]-glucosamine 3-sulfotransferases [EC?2.8.2.29?([heparan sulfate]-glucosamine 3-sulfotransferase 2) and EC?2.8.2.30?([heparan sulfate]-glucosamine 3-sulfotransferase 3) by being the most selective for a precursor of the antithrombin-binding site. It has a minimal acceptor sequence of: ¡úGlcNAc6S?¡úGlcA¡úGlcN2S*¡À6S¡úIdoA2S¡úGlcN2S¡ú, the asterisk marking the target (symbols as in?2-Carb-38?using ¡À to mean the presence or absence of a substituent, and > to separate a predominant structure from a minor one. Thus Glc(N2S>NAc) means a residue of glucosamine where the N carries a sulfo group mainly but occasionally an acetyl group.) [1-4]. It can also modify other precursor sequences within heparan sulfate but this action does not create functional antithrombin-binding sites. These precursors are variants of the consensus sequence: ¡úGlc(N2S>NAc)¡À6S¡úGlcA¡úGlcN2S*¡À6S¡úGlcA>IdoA¡À2S¡úGlc(N2S/NAc)¡À6S¡ú [5]. If the heparan sulfate substrate lacks 2-O-sulfation of GlcA residues, then enzyme specificity is expanded to modify selected glucosamine residues preceded by IdoA as well as GlcA [6].
Cofactor
History
Reactions 3′-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3′,5′-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate.

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