[heparan sulfate]-glucosamine 3-sulfotransferase 3 EC#: 2.8.2.30; 凯望编码 (ChemWhat Code): 1379115

英文名 [heparan sulfate]-glucosamine 3-sulfotransferase 3
Example Structure Example Structure of [heparan sulfate]-glucosamine 3-sulfotransferase 3 EC#: 2.8.2.30
别名 3-O-sulfotransferase 3, 3-O-sulfotransferase-3, 3-O-sulfotransferase-3A, 3-OST-3, 3-OST-3A, 3-OST-3A1, 3-OST-3B, 3-OST-3B1, 3-OST3, 3-OST3-B, 3-OST3A, 3OST3A1, D-glucosaminyl 3-O-sulfotransferase-3a, glucosaminyl 3-O-sulfotransferase 3a,3b, glucosaminyl 3-O-sulfotransferase-3, heparan sulfate 3-O-sulfotransferase, heparan sulfate 3-O-sulfotransferase 3, heparan sulfate 3-O-sulfotransferase 3B, heparan sulfate 3-O-sulfotransferase-3A1, heparan sulfate 6-O-sulfotransferase 3, heparan sulfate D-glucosamine 3-O-sulfotransferase 3A, heparan sulfate D-glucosamine 3-O-sulfotransferase 3B1, heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3A, heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3B1, heparan sulfate glucosamine 3-O-sulfotransferase, heparan sulfate sulfotransferase, heparan sulfate sulfotransferase 3-OST3A, heparin sulphate D-glucosaminyl 3-O-sulfotransferase 3B1, HS 3-O-sulfotransferase 3, HS 3-O-sulfotransferase isoform 3, HS 3-OST-3, Hs3st-3, HS3ST3A, HS3ST3A1, HS3ST3B, HS3ST3B1, HS6ST3, isoenzyme 3a, isoenzyme 3b, isoform 3a, isoform 3b, More
EC Number 2.8.2.30
CAS编号
Comments Two major substrates contain the tetrasaccharides: ¡úundetermined 2-sulfo-uronic acid¡úGlcN2S¡ú IdoA2S¡úGlcN*¡ú and ¡úundetermined 2-sulfo-uronic acid¡úGlcN2S¡ú IdoA2S¡úGlcN6S*¡ú (symbols as in?2-Carb-38) with modification of the?N-unsubstituted glucosamine residue (shown with an asterisk) [1,4]. Modification of selected sequences containing?N-sulfo-glucosamine residues cannot yet be excluded. The 3-O-sulfated heparan sulfate can be utilized by?Herpes simplex?virus type 1 as an entry receptor to infect the target cells [2]. There are two isozymes, known as 3-OST-3A?and 3-OST-3B, which have identical catalytic domains but are encoded by different mammalian genes [3]. The specificity of this enzyme differs from that of the other [heparan sulfate]-glucosamine 3-sulfotransferases. It is inefficient at modifying precursors of the antithrombin binding site (in contrast to EC?2.8.2.23?([heparan sulfate]-glucosamine 3-sulfotransferase 1)] and it does not modify glucosamine preceded by GlcA2S?[unlike EC?2.8.2.29?([heparan sulfate]-glucosamine 3-sulfotransferase 2)].
Cofactor
History
Reactions 3′-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3′,5′-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate.

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