| 英文名 |
hepoxilin-epoxide hydrolase |
| Example Structure |
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| 别名 |
HEH, hepoxilin epoxide hydrolase, hydrolase, hepoxilin epoxide |
| EC Number |
3.3.2.7 |
| CAS编号 |
122096-98-4 |
| Comments |
Converts hepoxilin A3?into trioxilin A3. Highly specific for the substrate, having only slight activity with other epoxides such as leukotriene A4?and styrene oxide [2]. Hepoxilin A3?is an hydroxy-epoxide derivative of arachidonic acid that is formed via the 12-lipoxygenase pathway [2]. It is probable that this enzyme plays a modulatory role in inflammation, vascular physiology, systemic glucose metabolism and neurological function [4]. In vertebrates, five epoxide-hydrolase enzymes have been identified to date: EC?3.3.2.6?(leukotriene-A4?hydrolase), EC?3.3.2.7?(hepoxilin-epoxide hydrolase), EC?3.3.2.9?(microsomal epoxide hydrolase), EC?3.3.2.10?(soluble epoxide hydrolase) and EC?3.3.2.11?(cholesterol 5,6-oxide hydrolase) [3]. |
| Cofactor |
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| History |
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| Reactions |
(5Z,9E,14Z)-(8-xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H(2)O = (5Z,9E,14Z)-(8-xi,11-xi,12S)-8,11,12-trihydroxyicosa-5,9,14- trienoate. |
