| 别名 |
ASH1, ASH1 HOMOLOG 2, ASHH2, histone H3 lysine 36 methyltransferase, histone H3 methyltransferase, histone H3K36 methyltransferase, histone lysine methyltransferase, histone lysine methyltransferases, histone methyltransferase, HMTase, huntingtin interacting protein B, HYPB, NSD2, nuclear receptor SET domain 2, SDG724, SDG8, SET domain containing protein 2, SET domain group protein 724, SET2, SETD2, setd3, Whsc1, Wolf-Hirschhorn Syndrome candidate 1 |
| Comments |
The enzyme, characterized from yeast, catalyses the successive methylation of lysine36 of histone H3 (H3K36), forming the trimethylated form. These modifications influence the binding of chromatin-associated proteins. The enzyme couples the methylation reactions with transcriptional elongation through an interaction with the large subunit of RNA polymerase II. In mammals this activity is catalysed by two different enzymes, EC 2.1.1.357, [histone H3]-lysine36 N-dimethyltransferase and EC 2.1.1.358, [histone H3]-dimethyl-L-lysine36 N-methyltransferase. |
![Example Structure of [histone H3]-lysine36 N-trimethyltransferase EC#: 2.1.1.359](/wp-content/uploads/enzyme-structure/2.1.1.359.jpg)