[histone H4]-N-methyl-L-lysine20 N-methyltransferase EC#: 2.1.1.362 • ChemWhat中文网

[histone H4]-N-methyl-L-lysine20 N-methyltransferase EC#: 2.1.1.362; 凯望编码 (ChemWhat Code): 1376648


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英文名	[histone H4]-N-methyl-L-lysine20 N-methyltransferase
Example Structure
别名	histone H4 lysine20 di- and trimethyltransferase, histone H4-K20 trimethyltransferase,, histone methyltransferase, Hmt4-20/Suv4-20, KMT5C, papA2, SUV39H1, SUV420H2
EC Number	2.1.1.362
CAS编号
Comments	This entry describes a group of enzymes that catalyse a single methylation of monomethylated lysine20 of histone H4 (H4K20m1, generated by EC 2.1.1.361, [histone H4]-lysine20 N-methyltransferase), forming the dimethylated form. This modification is broadly distributed across the genome and is likely important for general chromatin-mediated processes. The double-methylated form of lysine20 in histone H4 is the most abundant methylation state of this residue and is found on ~80% of all histone H4 molecules. Full activity of the enzyme requires that the lysine at position 9 of histone H3 is trimethylated. Formerly EC 2.1.1.43.
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