hyaluronan synthase EC#: 2.4.1.212 • ChemWhat | Database of Chemicals & Biologicals

hyaluronan synthase EC#: 2.4.1.212; 凯望编码 (ChemWhat Code): 1377510


认证生产商
想要被列为认证生产商 (需要通过认证)?	请下载并填写这份表格并发邮件到approved-manufacturers@chemwhat.com


其他供应商
Watson International Limited	访问Watson官网

英文名	hyaluronan synthase
Example Structure
别名	CHAS2, CHAS3, CPS1, DG42 protein, HA synthase, HA synthase 3, HA1, HA2, HA3, HAS, HAS-1, HAS1, Has2, Has3, HASs, HsHAS1, HuHAS1, hyaluronan synthase, hyaluronan synthase 1, hyaluronan synthase 2, hyaluronan synthase 3, hyaluronan synthase-1, hyaluronan synthase-2, hyaluronan synthases, hyaluronan synthethase, hyaluronate synthase, hyaluronate synthetase, hyaluronic acid synthase, hyaluronic acid synthetase, More, PmHAS, seHAS, XHAS1, XHAS2, XHAS3
EC Number	2.4.1.212
CAS编号
Comments	The enzyme from Streptococcus Group A and Group C requires Mg2+. The enzyme adds GlcNAc to nascent hyaluronan when the non-reducing end is GlcA, but it adds GlcA when the non-reducing end is GlcNAc [3]. The enzyme is highly specific for UDP-GlcNAc and UDP-GlcA; no copolymerization is observed if either is replaced by UDP-Glc, UDP-Gal, UDP-GalNAc or UDP-GalA. Similar enzymes have been found in a variety of organisms.
Cofactor	Mg2+
History
Reactions	(1) UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N- acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) = Udp + N-acetyl- beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D- glucosaminyl-(1->4)-(nascent hyaluronan). (2) UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D- glucuronosyl-(1->3)-(nascent hyaluronan) = Udp + beta-D-glucuronosyl- (1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)- (nascent hyaluronan).