| 英文名 |
hydroperoxy icosatetraenoate dehydratase |
| Example Structure |
 |
| 别名 |
ALOXE3, eLOX-3, eLOX3, epidermal lipoxygenase-3, epidermal LOX type 3, epidermis-type lipoxygenase 3, hepoxilin synthase |
| EC Number |
4.2.1.152 |
| CAS编号 |
|
| Comments |
Binds Fe2+. The mammalian enzymes accept a range of hydroperoxy icosatetraenoates (HPETE). The human enzyme has highest activity with (12R)-HPETE, followed by (12S)-HPETE and (15R)-HPETE with much lower efficiency. The murine enzyme has highest activity with (8R)-HPETE followed by (8S)-HPETE. All HPETE isoforms are converted to the corresponding oxoicosatetraenoate forms (KETE) [2]. The enzymes also catalyse the reaction of EC?5.4.4.7, hydroperoxy icosatetraenoate isomerase. |
| Cofactor |
Fe2+ |
| History |
|
| Reactions |
A hydroperoxy icosatetraenoate = an oxoicosatetraenoate + H(2)O. |
