| 英文名 |
infectious pancreatic necrosis birnavirus Vp4 peptidase |
| Example Structure |
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| 别名 |
avian infectious busrsal disease birnavirus Vp4 endopeptidase, blotched snakehead birnavirus endopeptidase, Drosophila X virus Vp4 protease, equine arterivirus serine peptidase, infectious pancreatic necrosis birnavirus Vp4 protease, NS, NS protease, S50.001, VP4 |
| EC Number |
3.4.21.115 |
| CAS编号 |
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| Comments |
Infectious pancreatic necrosis virus (IPNV) is a birnavirus that causes an acute, contagious disease in young salmonid fish [2]. As with most viruses that infect eukaryotic cells, the proteolytic processing of viral precursor proteins is a crucial step in the life cycle of this virus [2]. pVP2 is converted into VP2 by cleavage near the carboxy end of pVP2. This cleavage is most likely due to host-cell proteases rather than VP4 [2,3]. Differs from most serine peptidases in not having the catalytic triad Ser-His-Asp [2]. Belongs in peptidase family?S50. |
| Cofactor |
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| History |
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| Reactions |
Cleaves the (Ser/Thr)-Xaa-Ala-|-(Ser/Ala)-Gly motif in the polyprotein NH(2)-pVP2-VP4-VP3-Cooh of infectious pancreatic necrosis virus at the pVP2-VP4 and VP4-VP3 junctions. |
