interstitial collagenase EC#: 3.4.24.7 • ChemWhat中文网

interstitial collagenase EC#: 3.4.24.7; 凯望编码 (ChemWhat Code): 1380945


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英文名	interstitial collagenase
Example Structure
别名	azocollase, collagen peptidase, collagen protease, collagenase, collagenase 1, collagenase A, collagenase MMP-1, collagenase-1, EC 3.4.99.5, ect-MMP-14, Fibroblast collagenase, HSFC, kollaza, macrophage matrix metalloproteinase, matrix metalloproteinase 1, matrix metalloproteinase-1, matrix metalloproteinase-18, matrix-metalloproteinase-1, membrane-type 1-MMP, metallocollagenase, metalloproteinase-1, MMP-1, MMP-12, MMP-14, MMP-1A, mmp1, MT1-MMP, Myocardial collagenase, nucleolysin, soycollagestin, TC1, tumor collagenase, vertebrate collagenase
EC Number	3.4.24.7
CAS编号	9001/12/1
Comments	The enzyme takes its name from substrates of the interstitial collagen group – types I, II and III, all of which are cleaved in the helical domain. However, ¦Á-macroglobulins are cleaved much more rapidly. The enzyme is widely distributed in vertebrate animals. Type example of peptidase family?M10.
Cofactor	Zn2+
History
Reactions	Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at 775-Gly-\|-Ile-776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1′ is a hydrophobic residue.