iodide peroxidase EC#: 1.11.1.8 • ChemWhat中文网

iodide peroxidase EC#: 1.11.1.8; 凯望编码 (ChemWhat Code): 1374828


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英文名	iodide peroxidase
Example Structure
别名	bromoperoxidase, DEHAL1, high-molecular weight-thyroid peroxidase, HMW-TPO, hrTPO, hTPO, iodide peroxidase-tyrosine iodinase, iodinase, iodoperoxidase (heme type), iodotyrosine deiodase, iodotyrosine deiodinase, monoiodotyrosine deiodinase, thyroid peroxidase, thyroperoxidase, TPO, TPOX, TPQ, tyrosine iodinase, vanadium bromoperoxidase, vBPO
EC Number	1.11.1.8
CAS编号	9031-28-1
Comments	Thyroid peroxidase catalyses the biosynthesis of the thyroid hormones L-thyroxine and triiodo-L-thyronine. It catalyses both the iodination of tyrosine residues in thyroglobulin (forming mono- and di-iodinated forms) and their coupling to form either L-thyroxine or triiodo-L-thyronine.
Cofactor	heme
History
Reactions	(1) 2 iodide + H(2)O(2) + 2 H(+) = diiodine + 2 H(2)O. (2) [Thyroglobulin]-L-tyrosine + iodide + H(2)O(2) = [thyroglobulin]-3- iodo-L-tyrosine + 2 H(2)O. (3) [Thyroglobulin]-3-iodo-L-tyrosine + iodide + H(2)O(2) = [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H(2)O. (4) 2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H(2)O(2) = [thyroglobulin]- L-thyroxine + [thyroglobulin]-aminoacrylate + 2 H(2)O. (5) [Thyroglobulin]-3-iodo-L-tyrosine + [thyroglobulin]-3,5-diiodo-L- tyrosine + H(2)O(2) = [thyroglobulin]-3,5,3′-triiodo-L-thyronine + [thyroglobulin]-aminoacrylate + 2 H(2)O.