| 英文名 |
isocitrate-homoisocitrate dehydrogenase |
| Example Structure |
 |
| 别名 |
3-carboxy-2-hydroxyadipate dehydrogenase, HICDH, homoisocitrate dehydrogenase, isocitrate-homoisocitrate dehydrogenase, More, Saci_2375, TK0280 |
| EC Number |
1.1.1.286 |
| CAS编号 |
|
| Comments |
Requres Mn2+ and K+ or NH4+ for activity. Unlike EC 1.1.1.41, isocitrate dehydrogenase (NAD+) and EC 1.1.1.87, homoisocitrate dehydrogenase, this enzyme, from Pyrococcus horikoshii, can use both isocitrate and homoisocitrate as substrates. The enzyme may play a role in both the lysine and glutamate biosynthesis pathways. |
| Cofactor |
(1)NH4+ or K+ (2)Mn2+ |
| History |
|
| Reactions |
(1) Isocitrate + NAD(+) = 2-oxoglutarate + CO(2) + Nadh. (2) (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD(+) = 2-oxoadipate + CO(2) + Nadh. |
