isoleucine N-monooxygenase EC#: 1.14.14.39; 凯望编码 (ChemWhat Code): 1375547
| 英文名 | isoleucine N-monooxygenase |
| Example Structure |  |
| 别名 | CYP79D1, CYP79D2, CYP79D3, CYP79D4, valine N-monooxygenase |
| EC Number | 1.14.14.39 |
| CAS编号 | |
| Comments | This cytochrome P-450 (heme-thiolate) enzyme, found in plants, catalyses two successive N-hydroxylations of L-isoleucine, the committed step in the biosynthesis of the cyanogenic glucoside lotaustralin. The product of the two hydroxylations, N,N-dihydroxy-L-isoleucine, is labile and undergoes dehydration followed by decarboxylation, producing the oxime. It is still not known whether the decarboxylation is spontaneous or catalysed by the enzyme. The enzyme can also accept L-valine, but with a lower activity. cf. EC 1.14.14.38, valine N-monooxygenase. Formerly EC 1.4.13.117. |
| Cofactor | heme-thiolate |
| History | |
| Reactions | L-isoleucine + 2 O(2) + 2 [reduced NADPH–hemoprotein reductase] = (1E,2S)-2-methylbutanal oxime + 2 [oxidized NADPH–hemoprotein reductase] + CO(2) + 3 H(2)O. |
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