| 英文名 |
L-2-aminoadipate reductase |
| Example Structure |
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| 别名 |
AAR, alpha-AAR, alpha-aminoadipate reductase, L-alpha-aminoadipic acid reductase, Lys1+, LYS2, Nps3 |
| EC Number |
1.2.1.95 |
| CAS编号 |
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| Comments |
This enzyme, characterized from the yeast Saccharomyces cerevisiae, catalyses the reduction of L-2-aminoadipate to (S)-2-amino-6-oxohexanoate during L-lysine biosynthesis. An adenylation domain activates the substrate at the expense of ATP hydrolysis, and forms L-2-aminoadipate adenylate, which is attached to a peptidyl-carrier protein (PCP) domain. Binding of NADPH results in reductive cleavage of the acyl-S-enzyme intermediate, releasing (S)-2-amino-6-oxohexanoate. Different from EC 1.2.1.31, L-aminoadipate-semialdehyde dehydrogenase, which catalyses a similar transformation in the opposite direction without ATP hydrolysis. |
| Cofactor |
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| History |
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| Reactions |
(S)-2-amino-6-oxohexanoate + NADP(+) + Amp + diphosphate = L-2- aminoadipate + Nadph + atp. |
