| 英文名 |
L-ornithine N5-monooxygenase [NAD(P)H] |
| Example Structure |
![Example Structure of L-ornithine N5-monooxygenase [NAD(P)H] EC#: 1.14.13.196](/wp-content/uploads/enzyme-structure/1.14.13.196.jpg) |
| 别名 |
abachelin monooxygenase, AfSidA, AMO, SidA, siderophore A |
| EC Number |
1.14.13.196 |
| CAS编号 |
|
| Comments |
A flavoprotein (FAD). The enzyme from the pathogenic fungus Aspergillus fumigatus catalyses a step in the biosynthesis of the siderophores triacetylfusarinine and desferriferricrocin, while the enzyme from the bacterium Kutzneria sp. 744 is involved in the biosynthesis of piperazate, a building block of the kutzneride family of antifungal antibiotics. Activity of the fungal enzyme is higher with NADPH, due to the fact that following the reduction of the flavin, NADP+ (but not NAD+) stabilizes the C4a-hydroperoxyflavin intermediate that oxidizes the substrate [3]. cf. EC 1.14.13.195, L-ornithine N5-monooxygenase (NADPH). |
| Cofactor |
FAD |
| History |
|
| Reactions |
L-ornithine + NAD(P)H + O(2) = N(5)-hydroxy-L-ornithine + NAD(P)(+) + H(2)O. |
