LACTOFERRIN CAS#: 146897-68-9; 凯望编码 (ChemWhat Code): 418567

IdentificationPhysical DataSpectra
Route of Synthesis (ROS)Safety and HazardsOther Data

Identification

英文名LACTOFERRIN
分子结构LACTOFERRIN CAS 146897-68-9
CAS编号 146897-68-9
别名COLOSTRUM;LACTOSIDEROPHILIN (BOVINE);LACTOTRANSFERRIN (BOVINE);LACTOFERRIN, HUMAN;LACTOFERRIN, HUMAN MILK;LACTOFERRIN;LACTOFERRIN (BOVINE);Lactoferricin B; H-Phe-Lys-Cys-Arg-Arg-Trp-Gln-Trp-Arg-Met-Lys-Lys-Leu-Gly-Ala-Pro-Ser-Ile-Thr-Cys-Val-Arg-Arg-Ala-Phe-OH
分子式C141H224N46O29S3
分子量3123.773
Canonical SMILES CC[C@H](C)[C@H]1C(=O
)N[C@H](C(=O)N[C@@H]
(CSSC[C@@H](C(=O)N[C
@H](C(=O)N[C@H](C(=O
)N[C@H](C(=O)N[C@H](
C(=O)N[C@H](C(=O)N[C
@H](C(=O)N[C@H](C(=O
)N[C@H](C(=O)N[C@H](
C(=O)N[C@H](C(=O)NCC
(=O)N[C@H](C(=O)N2CC
C[C@H]2C(=O)N[C@H](C
(=O)N1)CO)C)CC(C)C)C
CCCN)CCCCN)CCSC)CCCN
C(=N)N)Cc3c[nH]c4c3c
ccc4)CCC(=O)N)Cc5c[n
H]c6c5cccc6)CCCNC(=N
)N)CCCNC(=N)N)NC(=O)
[C@H](CCCCN)NC(=O)[C
@H](Cc7ccccc7)N)C(=O
)N[C@@H](C(C)C)C(=O)
N[C@@H](CCCNC(=N)N)C
(=O)N[C@@H](CCCNC(=N
)N)C(=O)N[C@@H](C)C(
=O)N[C@@H](Cc8ccccc8
)C(=O)O)[C@@H](C)O
InChI InChI=1S/C141H224N46O29S3/c1-11-77(6)111-133(212)186-112(80(9)189)134(213)183-106(130(209)184-110(76(4)5)132(211)176-97(49-32-61-161-141(155)156)120(199)170-93(45-28-57-157-137(147)148)116(195)166-78(7)113(192)180-103(136(215)216)66-82-36-16-13-17-37-82)74-219-218-73-105(182-123(202)90(42-22-25-54-142)167-114(193)87(145)65-81-34-14-12-15-35-81)129(208)173-95(47-30-59-159-139(151)152)118(197)171-96(48-31-60-160-140(153)154)122(201)178-102(68-84-70-163-89-41-21-19-39-86(84)89)127(206)174-98(51-52-108(146)190)124(203)179-101(67-83-69-162-88-40-20-18-38-85(83)88)126(205)172-94(46-29-58-158-138(149)150)119(198)175-99(53-63-217-10)125(204)169-91(43-23-26-55-143)117(196)168-92(44-24-27-56-144)121(200)177-100(64-75(2)3)115(194)164-71-109(191)165-79(8)135(214)187-62-33-50-107(187)131(210)181-104(72-188)128(207)185-111/h12-21,34-41,69-70,75-80,87,90-107,110-112,162-163,188-189H,11,22-33,42-68,71-74,142-145H2,1-10H3,(H2,146,190)(H,164,194)(H,165,191)(H,166,195)(H,167,193)(H,168,196)(H,169,204)(H,170,199)(H,171,197)(H,172,205)(H,173,208)(H,174,206)(H,175,198)(H,176,211)(H,177,200)(H,178,201)(H,179,203)(H,180,192)(H,181,210)(H,182,202)(H,183,213)(H,184,209)(H,185,207)(H,186,212)(H,215,216)(H4,147,148,157)(H4,149,150,158)(H4,151,152,159)(H4,153,154,160)(H4,155,156,161)/t77-,78-,79-,80+,87-,90-,91?,92-,93-,94?,95-,96?,97-,98-,99-,100-,101-,102-,103-,104?,105-,106?,107-,110-,111-,112-/m0/s1
InChI Key PHEGMCHJJYMADA-WDZJEJQUSA-N
Patent Information
No data available

Physical Data

AppearanceLight Red to Pink fine powder
Water SolubilityH2O: soluble 10 mg/mL
Melting Point>213°C (dec.)
PH5.2～7.2(20g/l, 25℃)
SensitivityHygroscopic

Spectra

No data available

Route of Synthesis (ROS)

Bovine Lactoferrine is isolated from skimmed milk or cheese whey via ion exchange and subsequent ultrafiltration steps. Finally it is dried by freeze drying or spraying and the large particles are sieved out. It is a virtually odorless, red to light pinkish powder.

Safety and Hazards

GHS Hazard StatementsNot Classified
For more detailed information, please visit ECHA C&L website

Other Data

TransportationNot dangerous goods
Store in cool and dry place free from toxic chemicals and odours. Storage temperature: Ambient
HS Code382200
StorageStore in cool and dry place free from toxic chemicals and odours. Storage temperature: Ambient
Storage humidity: <85%
Shelf Life2 years from production date, in original unopened packing under recommended storage conditions.
Market PriceUSD 1900/kg
Use Pattern
LACTOFERRIN CAS#: 146897-68-9 is a freeze-dried protein purified directly from premium quality, fresh bovine milk and/or whey. It has a high affinity for iron and, therefore, is an excellent inhibitor of a wide range microorganisms that require iron for growth. As well as being necessary for normal growth of intestinal cells, lactoferrine functions as an antioxidant in iron mediated oxidation reactions and as an anti-inflammatory agent. It also may play an important role in the transport of iron across the duodenal mucosa. These proprieties make lactoferrine particularly suitable for selected food and pharmaceutical products.
LACTOFERRIN CAS#: 146897-68-9 is a protein that occurs naturally in cows’ milk. It is an iron-binding glycoprotein of approximately 77 kDa and consists of a single polypeptide chain of 689 amino acids.

Lactoferrine, also known as lacto-transferrin, is a multifunctional protein of the transferrin family. The antimicrobial activity of lactoferrine is related to its affinity for Fe3 + (Therefore its high ability to compete in the
free state with iron-dependent microorganisms), and direct action on the outer membrane of negative Gram bacteria. Many of these studies show that lactoferrine has interesting anti-infective, Immunomodulator and promotional properties of proper bowel ecology. During antibiotic therapy, lactoferrine may on one side increase susceptibility of bacteria to drug therapies and on the other, in synergy with probiotics, promote the growth of beneficial bowel bacterial strains (Lactobacillus or Bifid-bacterium) that depend less on the availability of iron.

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