| 英文名 |
leukotriene-A4 hydrolase |
| Example Structure |
 |
| 别名 |
hydrolase, leukotriene A4, leukotriene A(4) hydrolase, leukotriene A4 hydrolase, leukotriene A4 hydrolase/aminopeptidase, leukotriene hydrolase A4, leukotriene-A4 hydrolase, leukotriene-A4-hydrolase, LT A4 hydrolase, LTA-4 hydrolase, LTA4 hydrolase, LTA4-h, LTA4H |
| EC Number |
3.3.2.6 |
| CAS编号 |
90119-07-6 |
| Comments |
This is a bifunctional zinc metalloprotease that displays both epoxide hydrolase and aminopeptidase activities [4,6]. It preferentially cleaves tripeptides at an arginyl bond, with dipeptides and tetrapeptides being poorer substrates [6] (see EC?3.4.11.6, aminopeptidase B). It also converts leukotriene A4?into leukotriene B4, unlike EC?3.2.2.10, soluble epoxide hydrolase, which converts leukotriene A4?into 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid [3,4]. In vertebrates, five epoxide-hydrolase enzymes have been identified to date: EC?3.3.2.6?(leukotriene-A4?hydrolase), EC?3.3.2.7?(hepoxilin-epoxide hydrolase), EC?3.3.2.9?(microsomal epoxide hydrolase), EC?3.3.2.10?(soluble epoxide hydrolase) and EC?3.3.2.11?(cholesterol-5,6-oxide hydrolase) [3]. |
| Cofactor |
Zn2+ |
| History |
|
| Reactions |
(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H(2)O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate. |
