lipid IVA 3-deoxy-D-manno-octulosonic acid transferase EC#: 2.4.99.12; 凯望编码 (ChemWhat Code): 1377852
| 英文名 | lipid IVA 3-deoxy-D-manno-octulosonic acid transferase |
| Example Structure |  |
| 别名 | 3-deoxy-D-manno-2-octulosonic acid transferase, 3-deoxy-D-manno-oct-2-ulosonic acid transferase, 3-deoxy-D-manno-oct-2-ulosonic acid transferases, 3-deoxy-D-manno-octulosonic acid transferase, 3-deoxy-manno-octulosonic acid transferase, beta-Kdo transferase, Kdo transferase, KdtA, KpsC, KpsS, LipA, LipB, mono-functional Kdo transferase, monofunctional KDO transferase, multi-functional Kdo-transferase, WaaA, WaaAAAE |
| EC Number | 2.4.99.12 |
| CAS编号 | |
| Comments | The bifunctional enzyme from Escherichia coli transfers two 3-deoxy-D-manno-octulosonate residues to lipid IVA (cf. EC 2.4.99.13 [(KDO)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase]) [1]. The monofunctional enzymes from Aquifex aeolicus and Haemophilus influenzae catalyse the transfer of a single 3-deoxy-D-manno-octulosonate residue from CMP-3-deoxy-D-manno-octulosonate to lipid IVA [2,3]. The enzymes from Chlamydia transfer three or more 3-deoxy-D-manno-octulosonate residues and generate genus-specific epitopes [4]. |
| Cofactor | |
| History | |
| Reactions | Lipid IV(A) + CMP-beta-Kdo = alpha-Kdo-(2->6)-lipid IV(A) + Cmp. |
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