| 英文名 |
lovastatin nonaketide synthase |
| Example Structure |
 |
| 别名 |
LNKS, lovastatin nonaketide synthase, LovB, synthase, lovastatin nonaketide |
| EC Number |
2.3.1.161 |
| CAS编号 |
235426-97-8 |
| Comments |
This fungal enzyme system comprises a multi-functional polyketide synthase (PKS) and an enoyl reductase. The PKS catalyses many of the chain building reactions of EC 2.3.1.85, fatty-acid synthase system, as well as a reductive methylation and a Diels-Alder reaction, while the reductase is responsible for three enoyl reductions that are necessary for dihydromonacolin L acid production. |
| Cofactor |
|
| History |
|
| Reactions |
9 malonyl-CoA + 11 Nadph + S-adenosyl-L-methionine + holo-[lovastatin nonaketide synthase] = dihydromonacolin L-[lovastatin nonaketide synthase] + 9 CoA + 9 CO(2) + 11 NADP(+) + S-adenosyl-L-homocysteine + 6 H(2)O. |
