mannan-binding lectin-associated serine protease-2 EC#: 3.4.21.104; 凯望编码 (ChemWhat Code): 1380642

英文名 mannan-binding lectin-associated serine protease-2
Example Structure Example Structure of mannan-binding lectin-associated serine protease-2 EC#: 3.4.21.104
别名 CCP1-CCP2-SP, Mannan-binding lectin associated serine protease-2, mannan-binding lectin-associated serine protease, mannan-binding lectin-associated serine protease 2, mannan-binding lectin-associated serine protease-2, mannose-binding lectin-associated serine protease 2, mannose-binding lectin-associated serine protease-2, mannose-binding lectin-associated-serine protease-2, Map19, MASP, MASP-2, MASP-2A, MASP-2K, MASP2, MBL-associated serine protease, MBL-associated serine protease 2, MBL-associated serine protease-2, MBL-associated-serine protease-2, MBL-MASP, MBL/ficolin-associated serine protease, MBP-associated serine protease, MBP-associated serine protease 2, MBP-associated serine protease-2, S01.229
EC Number 3.4.21.104
CAS编号
Comments Mannan-binding lectin (MBL) recognizes patterns of neutral carbohydrates, such as mannose and?N-acetylglucosamine, on a wide range of microbial surfaces and is able to initiate activation of the lectin pathway of complement [7]. This enzyme displays C1?s?-like esterolytic activity (cf. EC?3.4.21.42, complement subcomponent C1?s?). It also cleaves C4 and C2 with efficiencies that are relatively higher than those of EC?3.4.21.42?[3]. Belongs in peptidase family?S1A.
Cofactor
History
Reactions Selective cleavage after Arg-223 in complement component C2 (-Ser- Leu-Gly-Arg-|-Lys-Ile-Gln-Ile) and after Arg-76 in complement component C4 (-Gly-Leu-Gln-Arg-|-Ala-Leu-Glu-Ile).

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