mannosyl-oligosaccharide 1,2-alpha-mannosidase EC#: 3.2.1.113; 凯望编码 (ChemWhat Code): 1379998

英文名 mannosyl-oligosaccharide 1,2-alpha-mannosidase
Example Structure Example Structure of mannosyl-oligosaccharide 1,2-alpha-mannosidase EC#: 3.2.1.113
别名 (alpha1,2)-mannosidase-I, 1,2-alpha-mannosidase, alpha-1,2 mannosidase I, alpha-1,2-mannosidase, alpha-1,2-mannosidase IC, alpha-1,2-mannosidaseI, alpha-1-2-mannosidase, alpha-mannosidase, alpha1,2-mannosidase, alpha1,2-mannosidase E-I, alpha1,2-mannosidase E-II, alpha1,2-specific exomannosidase, alpha1-2-mannosidase I, At1g51590, At3g21160, D2030.1, endoplasmic reticulum mannosidase I, ER alpha-1,2-mannosidase, ER alpha1,2-mannosidase I, ER mannosidase I, ERManI, exo-alpha-1,2-mannanase, FmanIBp, fungal alpha-1,2-mannosidase, glycoprotein processing mannosidase I, Golgi alpha-mannosidase I, Golgi alpha1,2-mannosidase I, Golgi alpha1,2-mannosidase IA, Golgi alpha1,2-mannosidase IB, Golgi alpha1,2-mannosidase IC, Golgi alpha1,2-mannosidase II, GolgiManI, HMIC, Htm1 protein, Htm1p, Man(9)-alpha-mannosidase, MAN1A1, MAN1A2, MAN1B1, MAN1C1, Man1p, Man9-mannosidase, Man9GlcNAc2-specific processing alpha-mannosidase, ManI, MANIa, ManIA2, MANIb, ManIC, mannose-9 processing alpha-mannosidase, mannosidase 1A, mannosidase 1B, mannosidase I, mannosidase, exo-1,2-alpha-, Mas1, MGG_00994.6, MIa, MIa,b,c, MIb, MIc, MII, MIIx, MNS1, MNS2, More, N-glycan processing class I alpha-1,2-mannosidase, processing alpha-1,2-mannosidase IC
EC Number 3.2.1.113
CAS编号 9068-25-1
Comments This family of mammalian enzymes, located in the Golgi system, participates in the maturation process of?N-glycans that leads to formation of hybrid and complex structures. The enzymes catalyse the hydrolysis of the four (1¡ú2)-linked ¦Á-D-mannose residues from the Man9GlcNAc2?oligosaccharide attached to target proteins as described in reaction (1). Alternatively, the enzymes act on the Man8GlcNAc2?isomer formed by EC?3.2.1.209, endoplasmic reticulum Man9GlcNAc2?1,2-¦Á-mannosidase, as described in reaction (2). The enzymes are type II membrane proteins, require Ca2+, and use an inverting mechanism. While all three human enzymes can catalyse the reactions listed here, some of the enzymes can additionally catalyse hydrolysis in an alternative order, generating additional isomeric intermediates, although the final product is the same. The names of the isomers listed here are based on a nomenclature system proposed by Prien et al [7].
Cofactor
History
Reactions Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2)

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